Company Summary:
Quotient Therapeutics Ltd is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS). We are an equal opportunity employer.

Position Summary:

We are seeking a molecular biologist to support development of Quotient’s genotyping platform. The role involves the development of innovative next generation sequencing workflows and supporting assays. This role is based in the vicinity of Cambridge UK and will be primarily based on site.

Key Responsibilities:

• Be an active member of the Assay Development team, conducting bench-based experiments
• Adapt and optimise cutting-edge Next-Generation Sequencing (NGS) library preparation methods
• Develop and run oligonucleotide assays to support NGS library prep optimisation
• Optimise procedures for DNA isolation, quantification and quality assessment from different sample sources
• Develop standard operating procedures for new versions of assays to enable smooth transfer of processes to Quotient’s pipeline
• Contribute to the technical assessment of novel tools/methods to support Quotient’s overarching goals
• Provide supervision and training for more junior lab members and/or technicians.
• Maintain detailed records of results and communicate key findings to stakeholders across the company, both in written and presentation formats.
• Collaborate closely with other team members across the organization.

Requirements:

• BSc/MSc in molecular biology or a related field with 6+ years research experience or equivalent.
• Understanding of NGS assay workflows with hands-on experience in NGS library preparation.
• Experience in a range of molecular biology assays including PCR, qPCR, nucleic acid purification and quantification.
• Experience with analysis of oligonucleotides, e.g. LC-MS
• A high degree of energy and attention to detail, and a passion for problem-solving.
• A desire to contribute to technologies that will enable the creation of transformative medicines for patients with serious diseases.
• Candidates with experience in some of the following areas will be preferred: (a) Development or use of high-sensitivity molecular techniques and tools (b) Use of lab automation devices

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.