What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.
With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 11 programs ongoing with plans to have more than 15 programs in 2024. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

Position Summary:

Pioneering Medicines is seeking an ambitious, innovative and highly collaborative Principal Scientist/Associate Director to join our Biology and Pharmacology team. The position supports early discovery programs by leading the cross-functional effort from screening to DC nomination. Success in this role requires excellent communication and collaborative skills with a deep understanding of the biology and pharmacology of the program needs.  This role will require identifying risk, managing mitigation strategies, and working with internal and external partners to develop and execute research plans. While the candidate should have breadth and depth in biology and pharmacology, experience using LNP-mediated delivery is preferred. The candidate will be well supported by scientific leaders to develop experience and expertise in drug discovery, pharmacology and IND-enabling studies. We are looking for adaptive and scientifically curious individuals who embrace our core values of putting people and patients first, in an environment that encourages growth and learning.

Key Responsibilities:

• Oversee research components of discovery programs within cross-functional teams as a matrix lead, guiding projects from lead ID to preclinical development stages
• Work closely with scientists collaboratively to create strategic plans for discovery programs effectively communicating outcomes and contributing to team meetings, scientific discussions, and project planning
• Collaborate with cross-functional colleagues and external partners for successful execution/completion of projects
• Drive the planning and execution of experiments to generate comprehensive data packages to enable decision-making according to timelines
• Communicate and interpret key datasets to the leadership team at governance meetings and research meetings
• Mentor research associate level colleagues with technical expertise and scientific knowledge 

Required Qualifications

• PhD in biology, molecular biology, biochemistry, pharmacology or related field
•  5+ years of industry or biotech experience
• Experienced in advancing programs from screening to DC nomination, with additional experience in IND-enabling activities being preferred.
• Excellent communication skills that convey clear and timely progress updates internally and with external partners
• Experience as lead scientist with external partners with high value placed on collaboration and communication
• Experience with multiple modalities (e.g. genetic medicines, biologics, small molecules) and multiple therapeutic areas. LNP-mediated delivery experience is preferred
• Experience in in vitro and in vivo pharmacology, in vivo model development, in vitro/ex vivo assay development, and mechanism of action workstreams

About Flagship Pioneering:

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

 

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