What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients through looking at and treating disease in a revolutionary way?

About Vesalius

Vesalius Therapeutics is pioneering a revolutionary platform to generate breakthrough treatments for common diseases.  Vesalius’ platform uses large-scale human genetics, genomics, stem cell studies and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Efficiently identifying these intervention points and the patients most likely to benefit from these novel therapies will enable smaller, shorter clinical trials with a higher probability of success. Vesalius was founded in 2019 by Flagship Pioneering. For more information visit vesaliustx.com, or follow us on X and LinkedIn.

About the Position

Vesalius Therapeutics is seeking a talented Senior Scientist with broad expertise in utilizing human induced pluripotent stem cells (iPSCs) to best incorporate the human genetic context of common diseases into disease modeling. In this role, you will be an essential part of an interdisciplinary team that uses state-of-the-art technologies to enhance the throughput and physiological relevance of cellular models to discover novel therapeutic targets. This role provides a unique opportunity to apply iPSC technologies to support target discovery. To succeed, you will be a collaborative team player who thrives in a dynamic, fast-paced environment.

Responsibilities

• Lead the establishment and execution of protocols to scale up the generation of iPSC models of human diseases involving CNS and peripheral organ cell types. Large-scale tissue culture and automation experience is preferable.
• Apply state-of-the-art technologies, including iPSCs, Organoids, and CRISPR/Cas genome editing.
• Development and execution of methods for screening in iPSC disease models at scale.
• Independently perform research requiring cell biology techniques, including human stem cell culture, cell-based assays, and analysis.
• Contribute to experimental planning, drawing on experience and literature reading.
• Lead collaborative work with team members to ensure lab experiments are well-planned and executed.
• Provide clear and complete documentation of experimental work in concise reports.

Qualifications 

• M.D. or Ph.D. degree in biology, genetics, neuroscience or a closely related field.
• 5-8 years of experience in an academic or industry setting.
• Proven expertise in developing human stem cell models and assays.
• Deep knowledge of human pluripotent stem cell culture systems, including the establishment and execution of differentiation protocols to achieve the scalable production of specific cell types with high quality and yield
• Experience with human pluripotent stem cell culture automation and high throughput systems.
• Self-motivation, an ability to work independently, highly organized with very strong attention to detail, and a desire to learn new skills.
• A record of innovative thinking, initiative and successful application of iPSC approaches to practical challenges in drug discovery.
• Flexibility and adaptability to changing priorities in a fast-paced, dynamic team environment.

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Vesalius is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. 

At Vesalius, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Vesalius Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Vesalius or its employees is strictly prohibited unless contacted directly by the Vesalius internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Vesalius, and Vesalius will not owe any referral or other fees with respect thereto.